Laboratory Values

Manufacturer Package Insert Recommendations

White blood cell count

< 1.5 x 109/L

Reduce peginterferon alfa-2b dose by 50% and reevaluate

< 1.0 x 109/L

Discontinue peginterferon alfa-2b until resolution

Absolute neutrophil count*

< 0.75 x 109/L

Peginterferon alfa-2a: reduce dose to 135 µg/wk and reevaluate
Peginterferon alfa-2b: reduce dose by 50% and reevaluate

< 0.50 x 109/L

Discontinue peginterferon alfa until resolution

Platelet count†

< 80,000/mm3

Peginterferon alfa-2b: reduce dose by 50% and reevaluate

< 50,000/mm3

Peginterferon alfa-2a: reduce dose to 90 µg/wk and reevaluate
Peginterferon alfa-2b: discontinue until resolution

< 25,000/mm3

Peginterferon alfa-2a: discontinue until resolution